Activity of antimicrobial peptide mimetics in the oral cavity: I. Activity against biofilms of Candida albicans
Identifieur interne : 005458 ( Main/Exploration ); précédent : 005457; suivant : 005459Activity of antimicrobial peptide mimetics in the oral cavity: I. Activity against biofilms of Candida albicans
Auteurs : J. Hua [États-Unis] ; R. Yamarthy [États-Unis] ; S. Felsenstein [États-Unis] ; R. W. Scott [États-Unis] ; K. Markowitz [États-Unis] ; G. Diamond [États-Unis]Source :
- Molecular Oral Microbiology [ 2041-1006 ] ; 2010-12.
English descriptors
- KwdEn :
- Acute leukemia, Albicans, Antibacterial activity, Antifungal, Antimicrob agents chemother, Antimicrob chemother, Antimicrobial, Antimicrobial activity, Antimicrobial peptides, Assay, Biochim biophys acta, Candida, Candida albicans, Candida species, Candidiasis, Cell viability, David perlin, Denture, Denture acrylic, Denture material, Denture stomatitis, Evasion strategy, Fungicidal, Fungicidal effect, Further examination, Hivinfected patients, Human saliva, Independent experiments, John wiley sons, John wiley sons peptide, Many advantages, Membrane activity, Membrane permeability, Metabolic activity, Microbiology, Mimetic compounds, Mimetics, Oral biology, Oral pathogens, Oropharyngeal candidiasis, Peptide, Peptide mimetics, Propidium iodide, Proteolytic cleavage, Results support, Second passage, Standard antifungal agents, Synergistic activity, Time course, Useful drugs, Viable organisms, Water lubricant.
- Teeft :
- Acute leukemia, Albicans, Antibacterial activity, Antifungal, Antimicrob agents chemother, Antimicrob chemother, Antimicrobial, Antimicrobial activity, Antimicrobial peptides, Assay, Biochim biophys acta, Candida, Candida albicans, Candida species, Candidiasis, Cell viability, David perlin, Denture, Denture acrylic, Denture material, Denture stomatitis, Evasion strategy, Fungicidal, Fungicidal effect, Further examination, Hivinfected patients, Human saliva, Independent experiments, John wiley sons, John wiley sons peptide, Many advantages, Membrane activity, Membrane permeability, Metabolic activity, Microbiology, Mimetic compounds, Mimetics, Oral biology, Oral pathogens, Oropharyngeal candidiasis, Peptide, Peptide mimetics, Propidium iodide, Proteolytic cleavage, Results support, Second passage, Standard antifungal agents, Synergistic activity, Time course, Useful drugs, Viable organisms, Water lubricant.
Abstract
Naturally occurring antimicrobial peptides hold promise as therapeutic agents against oral pathogens such as Candida albicans but numerous difficulties have slowed their development. Synthetic, non‐peptidic analogs that mimic the properties of these peptides have many advantages and exhibit potent, selective antimicrobial activity. Several series of mimetics (with molecular weight < 1000) were developed and screened against oral Candida strains as a proof‐of‐principle for their antifungal properties. One phenylalkyne and several arylamide compounds with reduced mammalian cytotoxicities were found to be active against C. albicans. These compounds demonstrated rapid fungicidal activity in liquid culture even in the presence of saliva, and demonstrated synergy with standard antifungal agents. When assayed against biofilms grown on denture acrylic, the compounds exhibited potent fungicidal activity as measured by metabolic and fluorescent viability assays. Repeated passages in sub‐minimum inhibitory concentration levels did not lead to resistant Candida, in contrast to fluconazole. Our results demonstrate the proof‐of principle for the use of these compounds as anti‐Candida agents, and their further testing is warranted as novel anti‐Candida therapies.
Url:
- https://api.istex.fr/document/EDCD7C52D8334007CA0FD9467BBD31638DBCE4E6/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992321
DOI: 10.1111/j.2041-1014.2010.00590.x
Affiliations:
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Le document en format XML
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Activity against biofilms of <hi rend="italic">Candida albicans</hi></title><author><name sortKey="Hua, J" sort="Hua, J" uniqKey="Hua J" first="J." last="Hua">J. Hua</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Oral Biology, UMDNJ‐New Jersey Dental School, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Yamarthy, R" sort="Yamarthy, R" uniqKey="Yamarthy R" first="R." last="Yamarthy">R. Yamarthy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Oral Biology, UMDNJ‐New Jersey Dental School, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Felsenstein, S" sort="Felsenstein, S" uniqKey="Felsenstein S" first="S." last="Felsenstein">S. Felsenstein</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Oral Biology, UMDNJ‐New Jersey Dental School, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Scott, R W" sort="Scott, R W" uniqKey="Scott R" first="R. W." last="Scott">R. W. Scott</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> PolyMedix, Inc., Radnor, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Markowitz, K" sort="Markowitz, K" uniqKey="Markowitz K" first="K." last="Markowitz">K. Markowitz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Oral Biology, UMDNJ‐New Jersey Dental School, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Diamond, G" sort="Diamond, G" uniqKey="Diamond G" first="G." last="Diamond">G. Diamond</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Oral Biology, UMDNJ‐New Jersey Dental School, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Molecular Oral Microbiology</title><title level="j" type="alt">MOLECULAR ORAL MICROBIOLOGY</title><idno type="ISSN">2041-1006</idno><idno type="eISSN">2041-1014</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="418">418</biblScope><biblScope unit="page" to="425">425</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-12">2010-12</date></imprint><idno type="ISSN">2041-1006</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">2041-1006</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute leukemia</term><term>Albicans</term><term>Antibacterial activity</term><term>Antifungal</term><term>Antimicrob agents chemother</term><term>Antimicrob chemother</term><term>Antimicrobial</term><term>Antimicrobial activity</term><term>Antimicrobial peptides</term><term>Assay</term><term>Biochim biophys acta</term><term>Candida</term><term>Candida albicans</term><term>Candida species</term><term>Candidiasis</term><term>Cell viability</term><term>David perlin</term><term>Denture</term><term>Denture acrylic</term><term>Denture material</term><term>Denture stomatitis</term><term>Evasion strategy</term><term>Fungicidal</term><term>Fungicidal effect</term><term>Further examination</term><term>Hivinfected patients</term><term>Human saliva</term><term>Independent experiments</term><term>John wiley sons</term><term>John wiley sons peptide</term><term>Many advantages</term><term>Membrane activity</term><term>Membrane permeability</term><term>Metabolic activity</term><term>Microbiology</term><term>Mimetic compounds</term><term>Mimetics</term><term>Oral biology</term><term>Oral pathogens</term><term>Oropharyngeal candidiasis</term><term>Peptide</term><term>Peptide mimetics</term><term>Propidium iodide</term><term>Proteolytic cleavage</term><term>Results support</term><term>Second passage</term><term>Standard antifungal agents</term><term>Synergistic activity</term><term>Time course</term><term>Useful drugs</term><term>Viable organisms</term><term>Water lubricant</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute leukemia</term><term>Albicans</term><term>Antibacterial activity</term><term>Antifungal</term><term>Antimicrob agents chemother</term><term>Antimicrob chemother</term><term>Antimicrobial</term><term>Antimicrobial activity</term><term>Antimicrobial peptides</term><term>Assay</term><term>Biochim biophys acta</term><term>Candida</term><term>Candida albicans</term><term>Candida species</term><term>Candidiasis</term><term>Cell viability</term><term>David perlin</term><term>Denture</term><term>Denture acrylic</term><term>Denture material</term><term>Denture stomatitis</term><term>Evasion strategy</term><term>Fungicidal</term><term>Fungicidal effect</term><term>Further examination</term><term>Hivinfected patients</term><term>Human saliva</term><term>Independent experiments</term><term>John wiley sons</term><term>John wiley sons peptide</term><term>Many advantages</term><term>Membrane activity</term><term>Membrane permeability</term><term>Metabolic activity</term><term>Microbiology</term><term>Mimetic compounds</term><term>Mimetics</term><term>Oral biology</term><term>Oral pathogens</term><term>Oropharyngeal candidiasis</term><term>Peptide</term><term>Peptide mimetics</term><term>Propidium iodide</term><term>Proteolytic cleavage</term><term>Results support</term><term>Second passage</term><term>Standard antifungal agents</term><term>Synergistic activity</term><term>Time course</term><term>Useful drugs</term><term>Viable organisms</term><term>Water lubricant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Naturally occurring antimicrobial peptides hold promise as therapeutic agents against oral pathogens such as Candida albicans but numerous difficulties have slowed their development. Synthetic, non‐peptidic analogs that mimic the properties of these peptides have many advantages and exhibit potent, selective antimicrobial activity. Several series of mimetics (with molecular weight < 1000) were developed and screened against oral Candida strains as a proof‐of‐principle for their antifungal properties. One phenylalkyne and several arylamide compounds with reduced mammalian cytotoxicities were found to be active against C. albicans. These compounds demonstrated rapid fungicidal activity in liquid culture even in the presence of saliva, and demonstrated synergy with standard antifungal agents. When assayed against biofilms grown on denture acrylic, the compounds exhibited potent fungicidal activity as measured by metabolic and fluorescent viability assays. Repeated passages in sub‐minimum inhibitory concentration levels did not lead to resistant Candida, in contrast to fluconazole. Our results demonstrate the proof‐of principle for the use of these compounds as anti‐Candida agents, and their further testing is warranted as novel anti‐Candida therapies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Hua, J" sort="Hua, J" uniqKey="Hua J" first="J." last="Hua">J. Hua</name></region><name sortKey="Diamond, G" sort="Diamond, G" uniqKey="Diamond G" first="G." last="Diamond">G. Diamond</name><name sortKey="Felsenstein, S" sort="Felsenstein, S" uniqKey="Felsenstein S" first="S." last="Felsenstein">S. Felsenstein</name><name sortKey="Markowitz, K" sort="Markowitz, K" uniqKey="Markowitz K" first="K." last="Markowitz">K. Markowitz</name><name sortKey="Scott, R W" sort="Scott, R W" uniqKey="Scott R" first="R. W." last="Scott">R. W. Scott</name><name sortKey="Yamarthy, R" sort="Yamarthy, R" uniqKey="Yamarthy R" first="R." last="Yamarthy">R. Yamarthy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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